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Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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He claims most all only get one semester of pharmacology in school and are woefully uninformed about the meds they hand out. Starts to explain why they always hand out samples.4.

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Keep all regular medical and psychiatric appointments. If you miss a dose, contact your doctor or pharmacist to establish a new dosing schedule.alk to your doctor if you have any questions or concerns.

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Antihistamines may cause a reduction in serum prolactin but this probably has no effect on breast milk production where lactation is established, and when the doses used are low.16th ed. Washington, DC: American Pharmacists Association; 2009: 5-81.

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Two days later I find that my daughter has been taken via ambulance and state police escort to a Psych hospital for having a mental break down and being on illegal drugs.An example is poison ivy. njury near the eye.

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They do study outcomes after TBI but I don't think they are usually able to account for people taking specific medications beforehand. Here is an article on TBI outcomes: Early predictors of outcome after mild traumatic brain injury UPFRONT an observational cohort study You could try searching Pubmed for this.This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

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He took twice the dose recommended by his physician due to trouble sleeping. Instead of becoming drowsy, he was quite restless.In rare instances, death is attributed to ingestion of lethal concentrations of the drug. Herein is a report of a toddler who died of lethal concentrations of diphenhydramine from topical application.

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