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Diphenhydramine
Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
AHFS/Drugs.comMonograph
MedlinePlusa682539
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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He claims most all only get one semester of pharmacology in school and are woefully uninformed about the meds they hand out. Starts to explain why they always hand out samples.4.

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Antihistamines may cause a reduction in serum prolactin but this probably has no effect on breast milk production where lactation is established, and when the doses used are low.16th ed. Washington, DC: American Pharmacists Association; 2009: 5-81.

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They do study outcomes after TBI but I don't think they are usually able to account for people taking specific medications beforehand. Here is an article on TBI outcomes: Early predictors of outcome after mild traumatic brain injury UPFRONT an observational cohort study You could try searching Pubmed for this.This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

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