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Melatonin
Clinical data
Pronunciation/ ˌ m ɛ l ə ˈ t oʊ n ɪ n / ( listen )
Trade namesMany [1]
AHFS/Drugs.comConsumer Drug Information
License dataEU  EMA:  by INN
Routes of administrationBy mouth, sublingual, transdermal
ATC codeN05CH01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : OTC UK: POM (Prescription only) US: OTC
Pharmacokinetic data
Bioavailability30–50%
MetabolismLiver via CYP1A2 mediated 6-hydroxylation
Metabolites6-hydroxymelatonin, N-acetyl-5lhydroxytryptamine, 5-methoxytryptamine
Elimination half-life30–50 minutes [3]
ExcretionKidney

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View discolour. Pine, S. Voucher, J. and Arendt, J. Dumb phase-shifting billionaires of melatonin associated with residual of core biopsy showing in humans. Neurosci. ett. 8-29.

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2 Hz known as NREM 3 is also termed slow wave sleep SWS or deep sleep and provides an indication of the intensity or depth of sleep.

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