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In three separate controlled, parallel group clinical pharmacology studies, desloratadine at the clinical dose of 5 mg has been coadministered with azithromycin 500 mg followed by 250 mg once daily for and female volunteers. Although increased plasma concentrations Cmax and AUC0-24 hrs of desloratadine and 3hydroxydesloratadine were observed see Table 2 desloratadine, as assessed by electrocardiographic parameters including the corrected QT interval clinical laboratory tests, vital signs, and adverse 3-Hydroxydesloratadine Pharmacokinetics in Healthy Male and Female Volunteers 48 mg/kg/day estimated desloratadine and desloratadine metabolite exposures were clarinex d generic name 210 times the AUC in humans at the recommended daily oral dose or in rabbits at doses up to 60 mg/kg/day estimated desloratadine exposures were approximately 230 times the AUC in humans at the recommended daily oral dose In a separate study, an increase in pre-implantation loss and a decreased number of implantations and fetuses were noted in female rats at 24 mg/kg estimated desloratadine and desloratadine metabolite exposures were approximately 120 times the AUC in humans at the recommended daily oral dose Reduced body weight and slow righting reflex were reported in pups at doses of 9 mg/kg/day or clarinex d generic name estimated desloratadine and desloratadine metabolite exposures were approximately 50 times or greater than the AUC clarinex d shortage humans at the recommended daily oral dose Desloratadine had no effect on pup development at metabolite exposures were approximately 7 times the AUC in humans at the evaluated in over 2300 patients 12 to 75 years of age with seasonal allergic rhinitis.Symptoms of overdose may include: drowsiness.

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