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Clopidogrel
Clinical data
Trade namesPlavix, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa601040
License dataEU  EMA:  by INN, US   FDA: Plavix
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationby mouth
ATC codeB01AC04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability>50%
Protein binding94–98%
Metabolismliver
Onset of action2 hours [2]
Elimination half-life7–8 hours (inactive metabolite)
Duration of action5 days [2]
Excretion50% kidney 46% biliary

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Background Dual therapy with aspirin and clopidogrel increases the risk of gastrointestinal bleeding. Therefore, co-therapy with a proton pump inhibitor (PPI ) is ...

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Dosage adjustment based solely on age does not appear to be necessary in geriatric patients. Experience is limited in patients with moderate creatinine clearance of 30-60 mL/minute or severe creatinine clearance of 5-15 mL/minute renal impairment.n the clopidogrel group, 2, 24 patients36.

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Rabeprazole uses these enzymes the least, being mostly converted to its thioether analog non-enzymatically. The clopidogrel bisulfate cost and specificity of five clopidogrel bisulfate cost PPIs omeprazole, esomeprazole, pantoprazole, lansoprazole, rabeprazole with regard to their inhibitory effects on the activities of four major human CYP enzymes CYP2C9, CYP2C19, CYP2D6, and CYP3A4 have been studied by Li et al Li et al.A decision should be made with your healthcare provider to avoid or discontinue breastfeeding when continuing Clopidogrel tablets is needed.

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200241120-00002 PubMed CrossRef Google Scholar 14. Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, et al.As a clopidogrel bisulfate cost, concomitant use of omeprazole or esomeprazole should be discouraged see section 4.

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Of patients with recent MI, stroke, or established peripheral arterial occlusive disease receiving clopidogrel in the CAPRIE study included chest pain, accidental injury, influenza-like symptoms, pain, fatigue, edema, hypertension, headache, dizziness, abdominal pain, dyspepsia, diarrhea, nausea, hypercholesterolemia, arthralgia, back pain, purpura bruising epistaxis, depression, upper respiratory tract infection, dyspnea, rhinitis, bronchitis, coughing, clopidogrel bisulfate 75 mg oral tablet, pruritus, and clopidogrel bisulfate 75 mg oral tablet tract infection.Figure 6: ffects of Adding Clopidogrel Bisulfate to Aspirin on the Combined Primary Endpoint across Baseline and Concomitant Medication Subgroups for the COMMIT Study The CAPRIE trial was a 19, 85-patient, 304-center, international, randomized, double-blind, parallel-group study comparing clopidogrel bisulfate 75 mg daily to aspirin 325 mg daily To be eligible to enroll, patients had to have: 1 recent history of myocardial infarction within 35 days 2 recent histories of ischemic stroke within 6 months with at least a week of residual neurological signs; and/or 3 established peripheral arterial disease PAD Patients received randomized treatment for an average of 1.

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