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Metronidazole
Clinical data
Pronunciation/ m ɛ t r ə ˈ n aɪ d ə z oʊ l /
Trade namesFlagyl, Metro, others
AHFS/Drugs.comMonograph
License dataUS   FDA: Metronidazole
Pregnancy categoryAU: B2 US: B (No risk in non-human studies)
Routes of administrationby mouth, topical, rectal, IV, vaginal
ATC codeA01AB17 ( WHO ) D06BX01 ( WHO ), G01AF01 ( WHO ), J01XD01 ( WHO ), P01AB01 ( WHO ), QP51AA01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability80% (by mouth), 60–80% (rectal), 20–25% (vaginal) [1] [2]
Protein binding20% [1] [2]
MetabolismHepatic [1] [2]
Elimination half-life8 hours [1] [2]
ExcretionUrine (77%), faeces (14%) [1] [2]

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Fekety R. Immigrants for the quantity and short of Clostridium raw-associated diarrhea and progression. American Nazi of Going, Gluten Parameters Berylliosis. Am J Gastroenterol. 1997 May. -50.

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Optic neuropathy, diplopia, myopia Frequency not reported: Optic neuropathy/neuritis, saccadic eye movement, blurred vision, decreased visual acuity, changed color vision, light sensitivity Ref Frequency not reported: Flattening of T-wave on ECG, tachycardia, palpitations, QT interval prolonged on ECG Ref Frequency not reported: Anorexia, decreased appetite Ref An increased incidence of gastrointestinal and certain extraintestinal cancers have been reported in flagyl vags suppository with Crohn's disease.

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All rights reserved.A high prevalence of C. trachomatis infection has been observed in women and men who were treated for chlamydial infection during the preceding several months.

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