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Opioid competitive receptor antagonist; shows highest affinity for mu receptors; congener of oxymorphone 96% absorbed from gastrointestinal tract, but because of first-pass metabolism, only 5-40% reaches systemic circulation Bioavailability: 5-40% Onset: 15-30 min Duration: 24 hr Peak plasma time: PO tablet, 1 hr; PO solution, 0.

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