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Clinical data
Trade namesCompro, others
Pregnancy categoryC (Au, U.S.)
Routes of administrationBy mouth, rectal, IM, IV
ATC codeN05AB04 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) UK: POM (Prescription only) but packs of 8 buccal tablets for nausea/vomiting associated with migraine are sold as pharmacy medicines, US: ℞-only
Pharmacokinetic data
BioavailabilityUnknown, but presumed substantial
Protein binding91–99%
MetabolismMainly hepatic (CYP2D6 and/or CYP3A4)
Elimination half-life4–8 hours, differs with the method of administration
ExcretionBiliary, (colored) inactive metabolites in urine

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Prochlorperazine synonymametil, antinaus, avotil, buccastem, carmetic, chloropernazinum, compro, darbazine, dhaperazine, emetiral, emidoxyn, melatil, mitil, nautisol, novamin, prochlor, prochlorperazin, prochlorperazinum, proclorperazina, procomp, promat, roumin, seratil, stemetil, stemzine, steremal, vergon
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A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Its been 30 hrs and I do prochlorperazine maleate tablet 5mg better than I did but I still feel a bit jumpy and not myself.NOTE: There have been occasional reports of sudden death in patients receiving phenothiazines. In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex.

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