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Prochlorperazine
Clinical data
Trade namesCompro, others
AHFS/Drugs.comMonograph
MedlinePlusa682116
Pregnancy categoryC (Au, U.S.)
Routes of administrationBy mouth, rectal, IM, IV
ATC codeN05AB04 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) UK: POM (Prescription only) but packs of 8 buccal tablets for nausea/vomiting associated with migraine are sold as pharmacy medicines, US: ℞-only
Pharmacokinetic data
BioavailabilityUnknown, but presumed substantial
Protein binding91–99%
MetabolismMainly hepatic (CYP2D6 and/or CYP3A4)
Elimination half-life4–8 hours, differs with the method of administration
ExcretionBiliary, (colored) inactive metabolites in urine

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