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( R )-(−)-citalopram (top), ( S )-(+)-citalopram (bottom)
Clinical data
Pronunciation/ s aɪ ˈ t æ l ə ˌ p r æ m, s ɪ -/ ; [2]
Trade namesCelexa, Cipramil, others (see below)
Pregnancy categoryUS: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classSelective serotonin reuptake inhibitor (SSRI) [1]
ATC codeN06AB04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability80% peak at 4 h [1]
MetabolismLiver (CYP3A4 and CYP2C19)
MetabolitesDesmethylcitalopram (DCT) and didesmethylcitalopram (DDCT)
Elimination half-life35 h
ExcretionMostly as unmetabolized citalopram, partly DCT and traces of DDCT in urine

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38 4 E11. doi: 0. 503/jpn.Patients and caregivers of patients should be alerted about the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present. Citalopram should not be used in the treatment of children and adolescents under the age of 18 years.

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Citalopram and demethylcitalopram are negligible inhibitors of CYP2C9, CYP2E1 and CYP3A4, and only weak inhibitors of CYP1A2, CYP2C19 and CYP2D6 as compared to other SSRIs established as significant inhibitors.In patients who develop these symptoms, increasing the dose may be detrimental. In patients with manic-depressive illness a change towards the manic phase may occur.

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Tremor, rigidity, myoclonus, hyperreflexia, incoordination seizures and/or gastrointestinal symptoms e.At steady state, the concentrations of demethylcitalopram and didemethylcitalopram in plasma are approximately one-half and one-tenth, respectively, that of the parent drug.

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By Dr Celeste A Jacque MD

Dr. Celeste A Jacque, MD is a Psychiatrist - Child & Adolescent Psychiatry practicing in Livingston, NJ She has not yet shared a personalized biography with

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Psychiatrist - Child & Adolescent Psychiatry

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